At that time, sdc was already supporting sidbi small industries development bank of india ; in a cluster modernization initiative in howrah. it was felt that shifting the sdct e r i technological intervention to howrah would also complement the ongoing collaboration between sdc and sidbi. however, this did not materialize. the reasons may be best understood by looking at the different approaches of the two initiatives. while the project focused on coming up with a benchmark longer-term solution, sidbi was more concerned with helping the smaller foundries deal with the immediate challenge posed by enforcement of environmental standards. the project itself could not develop a solution for smaller foundries as the operational culture in the typical small foundry did not match with the benchmarking approach adopted by the project. initially, the focus was on improving the energy efficiency of foundry units in the howrah cluster by demonstration of bop, and if necessary, adoption of the dbc. in early 1996, discussions were held with representatives of industry associations at howrah. based on the discussions, a detailed action plan was drawn up by the project. in the meanwhile, pollution control became the primary concern in howrah as well box 5 ; , with the supreme court stipulating deadlines for foundry units in howrah to put up gas cleaning systems. under the circumstances, the project modified its plan of action to address the needs and immediate concerns of the entrepreneurs in the cluster. in order to save time, the project decided to skip the planned demonstration of bop, and instead directly start with demonstration of an optimally designed dbc. it was felt that bop could be clubbed along with the technology demonstration. in parallel, the project decided to begin the exercise of designing a suitable pollution control system. Understanding the aetiology of pressure ulcers may contribute to a decrease in the high prevalence figures. the work described in chapters 3, 4, and 5 of this thesis is part of a research programme at the eindhoven university of technology, which aims at the understanding of the basic pathways whereby mechanical loading leads to soft tissue breakdown in the form of pressure ulcers. therefore, a hierarchical approach is adopted, incorporating experimental and numerical models at different length scales and levels of complexity bouten et al., 2003a, b ; . experimental models include a single cell model, as presented in this thesis, engineered tissue models bouten et al., 2001; breuls et al., 2003b ; , and an animal model bosboom et al., 2001, 2003 ; . numerical models include a single cell model chapter 4 ; , tissue models bosboom, 2001; breuls et al., 2003c ; , and a model of a supported human buttock contact oomens et al., 2003 ; . the elastic and viscoelastic properties of the muscle cells as characterised in this thesis will be used as an input for the multiscale computer model as described in breuls et al. 2003c ; . this will permit prediction of the internal microscopic mechanical environment from global, macroscopic loading conditions, such as interface pressures. the next question is how these internal conditions eventually lead to cellular damage and subsequent tissue breakdown. in earlier studies it has been hypothesised that cellular damage is caused by sustained cell deformation bosboom, 2001; bouten et al., 2001; breuls et al., 2003b ; . these studies, investigating the relationship between deformation and cellular damage in three-dimensional in vitro muscle models, indicated that cell damage increases with both magnitude and duration of compression. a study on cell damage evolution as a result of sustained compression at the single cell level should be performed in the future to complement the studies using in vitro muscle models. this would allow investigating the deformation-induced cell damage with time, independent of other factors such as neighbouring cells, the extracellular matrix, and three-dimensional tissue configuration. the developed loading device with its controlled environment within the cell chamber is particularly suitable to perform such long-term experiments. in this thesis, the deformation of single cells under compression was. 43 ; 9 apr avr 1998 09.04.1998 ; 51 ; 6 c08k 3 00, c08l 77 00, 25 18 c08k 3 00, 3: 00, 3: 38 ; c08l 77 00, 77: 00, 25: 18 ; c08l 25 18, 25: 00 ; 54 ; color stable flame retarded polyamide resin resine polyamide ignifugee a couleur stable 71 ; e.i. du pont de nemours and company [us us]; 1007 market street, wilmington, de 19898 us ; . for all designated states except pour tous les tats dsigns sauf us ; 72, 75 ; miyabo, atsushi [jp jp]; maison de issey takeda 507, 602, takeda jyobodaiin cho, fushimiku, kyoto 612 jp ; . koshida, reiko [jp jp]; 21419608, minowa, kohoku, yokohama 223 jp.

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